穂積 勝人

Hozumi Katsuto

  • 教授
  • 学位:博士(薬学)

基本情報

所属

  • Undergraduate School of Medicine / Faculty of Medicine
  • Graduate School of Engineering / Course of Biomedical Engineering
  • Graduate School of Medicine / Course of Advanced Medical Science
  • Graduate School of Medicine / Course of Medical Science

ジャンル

  • Drugs
  • Infectious Disease
  • Biotechnology

研究と関連するSDGs

  • Good Health and Well-Being
  • Quality Education
  • Industry, Innovation and Infrastructure

詳細情報

研究分野

  • Life sciences Immunology

論文

Macrophage-depleted young mice are beneficial in?vivo models to assess the translocation of Klebsiella pneumonia from the gastrointestinal tract to the liver in the elderly.

Investigating the immunological function of alpha-2-glycoprotein 1, zinc-binding in regulating tumor response in the breast cancer microenvironment.

Cyclic-di-AMP confers an invasive phenotype on Escherichia coli through elongation of flagellin filaments.

Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis.

Gas6 ameliorates intestinal mucosal immunosenescence to prevent the translocation of a gut pathobiont, Klebsiella pneumoniae, to the liver.

Correction: Expression of hormone receptors is associated with specific immunological profiles of the breast cancer microenvironment.

Expression of hormone receptors is associated with specific immunological profiles of the breast cancer microenvironment.

Adherent-invasive E. coli - induced specific IgA limits pathobiont localization to the epithelial niche in the gut.

Two distinct Notch signals, Delta-like 4/Notch1 and Jagged-1/Notch2, antagonistically regulate chemical hepatocarcinogenesis in mice

Transcription factor Zbtb1 interacts with bridging factor Lmo2 and maintains the T-lineage differentiation capacity of lymphoid progenitor cells.

Immunological profiles of the breast cancer microenvironment represented by tumor-infiltrating lymphocytes and PD-L1 expression.

Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium

A potential pathogenic association between periodontal disease and Crohn's disease.

Notch signaling supports the appearance of follicular helper T cells in the Peyer’s patches concomitantly with the reduction of regulatory T cells

LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice

共同研究?競争的資金等の研究課題

The molecular analysis of the structural basis of Notch1/Dll4 interaction for drug discovery.

Notch signaling in small bowel allograft rejection

Identification of miRNA which rescues EBF1 deficiency indispensable for B cell lineage commitment

Significance of Notch signaling for the regulation of T cell response to gut-derived antigen as neo-self

Molecular mechanisms for the maintenance of T cell differentiation potential and the determination of T cell fate

The exploration of new drug for the treatment of Notch-active tumor cells.

Analysis of collagen producing cell and new therapeutic target of TGF-b signal in colorectal fibrosis

Pathophysiological Interplay between Liver Fibrosis, Regeneration and Hepatocarcinogenesis from the Viewpoint of Stem/progenitor Cell Differentiation

Pathophysiological correlation between fibrogenesis and regeneration in murine liver via Notch/Jagged-1 signal

Regeneration of Fibrotic Liver through Modulation of Hepatic Stem Cell Niche and Differentiation of Bone Marrow Stem Cells

Study for the determination of cell fates by NotchL as environment factor

Identification of molecular mechanisms that link bone remodeling and hematopoietic homeostasis

Analysis of the molecular mechanism for the determination of cell fate and the tissue organization with Notch signaling

Investigative of diffentiation of pancreatic cells and application for treatments for chronic pancreatitis

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