Hadano Shinji

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Soymilk yogurt prepared using Pediococcus pentosaceus TOKAI 759m ameliorates cognitive function through gut microbiota modulation in high-fat diet mice.

Dysregulation of the autophgy-endolysosomal system in amyotrophic lateral sclerosis and frontotemporal dementia.

Preclinical alternative drug discovery programs for monogenic rare diseases. Should small molecules or gene therapy be used? The case of hereditary spastic paraplegias.

Rare CRHR2 and GRM8 variants identified as candidate factors associated with eating disorders in Japanese patients by whole exome sequencing.

Effect of PCDH19 missense mutations on cell-to-cell proximity and neuronal development under heterotypic conditions.

Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and frontotemporal dementia.

Genetic and clinical characteristics of ALS patients with NEK1 gene variants.

Central nervous system specific high molecular weight ALS2/alsin homophilic complex is enriched in mouse brain synaptosomes

De-erosion of X chromosome dosage compensation by the editing of XIST regulatory regions restores the differentiation potential in hPSCs

Personalized Treatment for Infantile Ascending Hereditary Spastic Paralysis Based on In Silico Strategies.

AI-based protein structure databases have the potential to accelerate rare diseases research: AlphaFoldDB and the case of IAHSP/Alsin

SQSTM1, a protective factor of SOD1-linked motor neuron disease, regulates the accumulation and distribution of ubiquitinated protein aggregates in neuron.

Impact of COVID-19 infection on clinical care: Insights from interviews with multidisciplinary healthcare professionals involved in amyotrophic lateral sclerosis patients.

High-throughput quantitative analysis of axonal transport in cultured neurons from SOD1H46R ALS mice by using a microfluidic device

The N-terminal intrinsically disordered region mediates intracellular localization and self-oligomerization of ALS2.

SQSTM1L341V variant that is linked to sporadic ALS exhibits impaired association with MAP1LC3 in cultured cells.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.

Alopecia areata susceptibility variant in MHC region impacts expressions of genes contributing to hair keratinization and is involved in hair loss.

Efficient differentiation and polarization of primary cultured neurons on poly(lactic acid) scaffolds with microgrooved structures.

ALS2, the small GTPase Rab17-interacting protein, regulates maturation and sorting of Rab17-associated endosomes.

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A new drug-delivery method to the central nervous system: study on novel proteins that regulate drug-permeability in the blood-brain barrier

An ALS2-linked functional cellular network-based study on molecular mechanisms of selective upper motor neuron degeneration in ALS

Analysis of the pathogenic mechanism of neurodegenerative diseases focusing on the functional disruption of early endosomes

Elucidation of microRNAs causing immune cell dysfunction by next generation sequencer in patients with lung cancer

Molecular mechanism for the maintenance of proteostasis in motor neurons

Toward a development of the novel drug-screening system based on monitoring autophagy dynamics

Towards a comprehensive understanding of molecular pathogenesis for amyotrophic lateral sclerosis

Elucidation of the physiological function of ALS2 and mechanism for motor neuron degeneration through the identification of ALS2 activators