Sakai Daisuke

教授
学位：博士（医学）

基本情報

所属

Undergraduate School of Medicine / Faculty of Medicine
Graduate School of Medicine / Course of Advanced Medical Science
Graduate School of Medicine / Course of Medical Science

ジャンル

Drugs
Lifestyle-Related Diseases

研究と関連するSDGs

詳細情報

研究分野

Life sciences Orthopedics

委員歴

AO Spine Japan Council Research Officer
Orthopaedic Research Society Journal of Orthopaedic Research Spine, Editor-in-Chief
Asia Pacific Spine Society (APSS) National Delegate (Japan)
Asia Pacific Orthopaedic Association (APOA) National Delegate (Japan)
Asia Pacific Orthopaedic Association The Journal of Orthopaedic Surgery, Basic Science Section Editor
North American Spine Society Fellow of the International Combine Orthopaedic Research Societies
Orthopaedic Research Society Journal of Orthopaedic Research, Editoria Review Board
International Society for the Study of Lumbar Spine Membership Committee (2019 chairman)
Orthopaedic Research Society Spine Section Membership Chair

受賞

2018 Berton Rahn Research Award
Incentive award
Spine Across the Sea 2006 Best Research Award
Best poster award
Prize of Imai
Prize of Seiikai
Research Encouragement Award
Overseas dispatch subsidy
International Society for the Study of Lumbar Spine Incentive award of Japan branch
Prize of Iwahara

論文

Simultaneous translation on two rods (ST2R) improves the correction and apex 2 translocation in adolescent patients with hypokyphotic scoliosis

Augmented, virtual and mixed reality in spinal surgery: A real-world experience

IVD progenitor cells: a new horizon for understanding disc homeostasis and repair

Effects of interleukin-17A in nucleus pulposus cells and its small-molecule inhibitors for intervertebral disc disease

Implantation of hyaluronic acid hydrogel prevents the pain phenotype in a rat model of intervertebral disc injury

Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins

Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs

Advancing the cellular and molecular therapy for intervertebral disc disease

Stem cell therapy for intervertebral disc regeneration: obstacles and solutions

Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc

Atelocollagen for culture of human nucleus pulposus cells forming nucleus pulposus-like tissue in vitro: Influence on the proliferation and proteoglycan production of HNPSV-1 cells

Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc

Differentiation of Mesenchymal Stem Cells Transplanted to a Rabbit Degenerative Disc Model

Transplantation of mesenchymal stem cells embedded in Atelocollagen? gel to the intervertebral disc: a potential therapeutic model for disc degeneration

書籍等出版物

Comprehensive biomaterials

講演?口頭発表等

Evaluating the Precision of Percutaneous Pedicle Screw Placement in Lateral Spine Surgery: A Retrospective Analysis of Intraoperative CT Navigation
Tie2-Optimized NP Cell Product Attenuates Across Mild to Severe Disc Degeneration: Unveiling Their Regenerative Potentials in a Canine Disc Degeneration Model

担当経験のある科目

clinical diagnostics
Human Relations (1)/Individualized Experiential Learning
Clinical Pathology 2
Research Planning
Human Relations (1)/Individualized Experiential Learning
basic medical studies
Clinical Pathology C
basic medical studies
basic medical studies
Clinical Pathology A
Medical Electives
Clinical Medicine B

所属学会

Orthopaedic Research Society
International Society for the Study of Lumbar Spine
North American Spine Society
American Academy of Orthopaedic Surgeons (AAOS)
Asia Pacific Orthopaedic Association (APOA)
Asia Pacific Spine Society (APSS)

共同研究?競争的資金等の研究課題

The investigation of the new small molecule inhibitors of IL-17A for intervertebral disc disease treatment by In Silico analysis

Basic development for reprogramming methods and translation of regenerative medicine in intervertebral disc cells

Effects of IL-17 on intervertebral disc degeneration and the investigation of the new small-molecule IL-17 inhibitor for treating degenerative discs

Analysis of transcription factors mediated by Wnt signal in intervertebral disc degeneration and search for therapeutic agents for low back pain

Intervertebral disc regeneration and transcriptional control of nucleus pulpous progenitor cells by in silico pharmacogenesis and iPS technology

Analysis of molecular mechanism of Wnt signal and arachidonic acid cascade in intervertebral disc degeneration

Isolation and application of progenitor cells from annulus fibrosus of the intervertebral disc

Analysis of appropriate cell source for efficient annulus fibrosis regeneration

Discovering the genetics , unde rstanding progenitor cell niche and transcriptional controls to harness the endogenous regene ration potentials of the interver tebral disc

Exploratory Research Program: ANNULUS FIBROSUS REPA IR

Identifying the origin and niche environment of nucleus pulposus progenitor cells of the intervertebral disc and its therapeutic applications

Identification endogenous disc p rogenitor cells , its role in hom eostasis of disc environment an d degeneration , and its use in stem cell based regeneration

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