
Ohtsuka Masato
- 教授
- 学位:博士(理学)
基本情報
所属
- Undergraduate School of Medicine / Faculty of Medicine
- Graduate School of Medicine / Course of Advanced Medical Science
- Graduate School of Medicine / Course of Medical Science
ジャンル
- Biotechnology
研究と関連するSDGs
詳細情報
研究キーワード
- Transgenic
- Gene therapy
- Genetic engineering
- mouse
- Genome editing
研究分野
- Life sciences Genomics
- Life sciences Laboratory animal science
論文
Targeted insertion of conditional expression cassettes into the mouse genome using the modified i-PITT
In vivo functional significance of direct physical interaction between Period and Cryptochrome in mammalian circadian rhythm generation
A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency
Abcb4-defect cholangitis mouse model with hydrophobic bile acid composition by in vivo liver-specific gene deletion
Recent Advances in the Production of Genome-Edited Animals Using <i>i</i>-GONAD, a Novel <i>in vivo</i> Genome Editing System, and Its Possible Use for the Study of Female Reproductive Systems
Bone marrow-derived fibroblast migration via periostin causes irreversible arthrogenic contracture after joint immobilization.
Delivering mRNAs to mouse tissues using the SEND system.
Improved Genome Editing via Oviductal Nucleic Acids Delivery (i-GONAD): Protocol Steps and Additional Notes.
Multiplexed genome editing by in vivo electroporation of Cas9 ribonucleoproteins effectively induces endometrial carcinoma in mice.
CRISPR-KRISPR: a method to identify on-target and random insertion of donor DNAs and their characterization in knock-in mice.
Gender-Difference in Hair Length as Revealed by Crispr-Based Production of Long-Haired Mice with Dysfunctional FGF5 Mutations.
Prototype mouse models for researching SEND-based mRNA delivery and gene therapy.
Use of anti-inhibin monoclonal antibody for increasing the litter size of mouse strains and its application to i-GONAD.
Cyclin D1 Binding Protein 1 Responds to DNA Damage through the ATM-CHK2 Pathway.
Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium.
GONAD: A new method for germline genome editing in mice and rats.
Novel reporter mouse models useful for evaluating in?vivo gene editing and for optimization of methods of delivering genome editing tools.
Indirect podocyte injury manifested in a partial podocytectomy mouse model.
Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer.
所属学会
- American Society of Gene & Cell Therapy
- International Society for Transgenic Technologies
- SOCIETY FOR REPRODUCTION AND DEVELOPMENT
- THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
- The Japanese Society for Genome Editing
- JAPANESE ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
共同研究?競争的資金等の研究課題
Analysis of genomic DNA in aging heart
Development of Organ- and Cell-specific In Vivo Genome Editing Technique as a Novel Approach for Cancer Gene Therapy
Development of Organ- and Cell-specific In Vivo Genome Editing Technique as a Novel Approach for Cancer Gene Therapy
Determination of chronic or intractable mechanisms induced by low bone quality with osteomacs and bone marrow derived stem cells interaction
Understanding of pathophysiology and development of treatment strategy for MRONJ based on the hierarchical structure of macrophages
Understanding of pathophysiology and establishment of new treatment strategy by determining the hierarchy of macrophages in medication-related osteonecrosis of the jaw
Establishment of gene expression system by intron modification and its application for the functional analysis of diabetes-related genes
Development of novel genome editing tool for gene therapy and its application to cancer therapy
Generation of gene modified mice using in situ genome editing system without microinjection
Molecular targeted therapy for MRONJ
Identification of miRNA which rescues EBF1 deficiency indispensable for B cell lineage commitment
The proposal of novel experimental system using original knockdown methods in mice
Development of microinjection-independent animal genome manipulation method
Role of calcium sensing receptor in Kidney Type B Intercalated Cells
Development of gene therapy for liver cirrhosis utilizing MMP13
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