Takashi Yahata

Փ��

Plasminogen activator inhibitor-1 promotes immune evasion in tumors by facilitating the expression of programmed cell death-ligand 1

Mitochondrial Electron Transport Chain Complex II Dysfunction Causes Premature Aging of Hematopoietic Stem Cells

Pterostilbene downregulates BCR/ABL and induces apoptosis of T315I-mutated BCR/ABL-positive leukemic cells.

Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium.

LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice.

Plasminogen activator inhibitor type-1 is a negative regulator of hematopoietic regeneration in the adipocyte-rich bone marrow microenvironment.

IMiDs uniquely synergize with TKIs to upregulate apoptosis of Philadelphia chromosome-positive acute lymphoblastic leukemia cells expressing a dominant-negative IKZF1 isoform.

Targeting of plasminogen activator inhibitor-1 activity promotes elimination of chronic myeloid leukemia stem cells.

Inhibition of plasminogen activator inhibitor-1 attenuates against intestinal fibrosis in mice.

Podoplanin is indispensable for cell motility and platelet-induced epithelial-to-mesenchymal transition-related gene expression in esophagus squamous carcinoma TE11A cells.

Blockade of plasminogen activator inhibitor-1 empties bone marrow niche sufficient for donor hematopoietic stem cell engraftment without myeloablative conditioning.

Increased Granulopoiesis in the Bone Marrow following Epstein-Barr Virus Infection

Role of exosomes as a proinflammatory mediator in the development of EBV-associated lymphoma.

Jagged1-induced Notch activation contributes to the acquisition of bortezomib resistance in myeloma cells.

TGF-��-induced intracellular PAI-1 is responsible for retaining hematopoietic stem cells in the niche.

Maintenance of Bone Homeostasis by DLL1-Mediated Notch Signaling.

Comparison of the Gene Expression Profiles of Human Hematopoietic Stem Cells between Humans and a Humanized Xenograft Model.

Common marmoset CD117(+) hematopoietic cells possess multipotency

Functional analysis of the SEPT9-ABL1 chimeric fusion gene derived from T-prolymphocytic leukemia.

Effective expansion of engrafted human hematopoietic stem cells in bone marrow of mice expressing human Jagged1.

��ͬ�о�?�������Y��Ȥ��о��n�}

Elucidation of stem cell motility mechanism and its application to regeneration and cancer therapy

Development of novel genome editing tool for gene therapy and its application to cancer therapy

An analysis for development of myelodysplastic syndrome and influence of ROS

Analysis of interraction of multiple myeloma cells and bone marrow stroma cells using xenograft models

The exploration of new drug for the treatment of Notch-active tumor cells.

Blockade of PAI-1 eliminates leukemic stem cells

Maintenance of bone homeostasis by DLL1-mediated Notch activation

Establishment of hematopoietic regeneration by the novel molecular targeting drug

In vivo analysis of gene mutations related to epigenetic alterations in acute myeloid leukemia

Development of experimentation systems related to personalized medicine using humanized NOG mice

Analysis of Multiple myeloma pahtophysiology using xenograft model having humanized BM microenvironment

DNA damage response in human hematopoietic stem cell

Genetic abnormality require their specific differentiation stage in leukemogenensis

Identification of molecular mechanisms that link bone remodeling and hematopoietic homeostasis

Analysis of repopulating dynamics of human hematopoietic stem cells

Molecular mechanism of leukemica stem cells maintenance in vivo

Establishment of human hematopoietic system model mouse for understanding the regulatory mechanisms of human hematopoiesis.

Establishment of a novel in vivo model of human leukemia