小見山 智義

KOMIYAMA TOMOYOSHI

  • 准教授
  • 学位:博士(理学)

基本情報

所属

  • Undergraduate School of Medicine / Faculty of Medicine
  • Graduate School of Medicine / Course of Advanced Medical Science
  • Graduate School of Medicine / Course of Medical Science

詳細情報

研究キーワード

  • Clinical genetics
  • neuroscience
  • molecular pharmacology
  • Comparative genomics
  • Molecular genetics

研究分野

  • Life sciences Genomics
  • Life sciences Clinical pharmacy
  • Life sciences Neuroscience - general

委員歴

  • PLOS ONE ;Editorial Board
  • biology (MDPI) ;Topical Advisory Panel Members
  • Japan Society of Neurovegetative Research Councillor
  • Frontiers in Genetics ;Guest Editor

受賞

  • Japan Society of Neurovegetative Research Paper Award The study of adenylate cyclase activity in NMS patients based on heterotype of α2B-AR gene
  • Japan Society of Neurovegetative Research Excellent Presentation Award The Clinical Study for Genetic Evaluation of α2B-AR Gene Polymorphism in Neurally Mediated Syncope
  • Society of Evolutionary Studies, Japan Best poster award An evolutionary Origin and Selection Process of Goldfish
  • Society of Evolutionary Studies, Japan Best poster award Genetic diversity and cultural background of gamecocks

論文

Differential Effects of Landiolol in Patients with Atrial Fibrillation and Atrial Tachycardia

Onset Mechanisms and Prognosis of Neurally Mediated Syncope

Effects of Genetic Mutation Sites in ADR Genes on Modern Chickens Produced and Domesticated by Artificial Selection

Gender Differences in Takotsubo Syndrome

RNA-seq and Mitochondrial DNA Analysis of Adrenal Gland Metastatic Tissue in a Patient with Renal Cell Carcinoma

Clinical Significance of the Head-Up Tilt Test in Improving Prognosis in Patients with Possible Neurally Mediated Syncope

Diagnosis and prevention of the vasodepressor type of neurally mediated syncope in Japanese patients

Examination of gender differences in patients with takotsubo syndrome according to left ventricular biopsy: two case reports

Alopecia areata susceptibility variant in MHC region impacts expressions of genes contributing to hair keratinization and is involved in hair loss

Analysis of the source of aggressiveness in gamecocks

Alopecia areata susceptibility variant identified by MHC risk haplotype sequencing reproduces symptomatic patched hair loss in mice.

Whole genome sequencing of Entamoeba nuttalli reveals mammalian host-related molecular signatures and a novel octapeptide-repeat surface protein.

D-loop Mutations in Renal Cell Carcinoma Improve Predictive Accuracy for Cancer-Related Death by Integrating with Mutations in the NADH Dehydrogenase Subunit 1 Gene

Impact of rhabdoid differentiation on postoperative outcome for patients with N0M0 renal cell carcinoma

Neurally mediated syncope diagnosis based on adenylate cyclase activity in Japanese patients

Analysis of candidate idarubicin drug resistance genes in MOLT-3 cells using exome nuclear DNA

Verification of the international society of urological pathology recommendations in Japanese patients with clear cell renal cell carcinoma

The Study of Adenylate Cyclase Activity in NMS Patients

Relationship between adenylate cyclase activity and polymorphic sites on α2B-AR gene in neurally mediated syncope

The study of adenylate cyclase activity in NMS patients based on heterotype of α2B-AR gene

書籍等出版物

  • Visual Reference Book of GENE
  • A Statical Approach to Genetic Epidemiology(second edition
  • How was Shamo (game cock) made from chickens? -A study on the cultural intervention of Japanese ancient people related to the genetic formation of game cocks-

講演?口頭発表等

  • Examination of resting adenylate cyclase activity in orthostatic dysregulation
  • Analysis of RNA-seq and mitochondrial DNA mutation in adrenal gland metastatic tissue from renal cell carcinoma
  • Relationship between adenylate cyclase activity and glutamic acid repeat number polymorphism in NMS patients during HUT
  • Fluctuations in adenylate cyclase activity in patients with childhood orthostatic dysregulation
  • Diagnosis and preventative treatment of patients with neuromodulated syncope (vasodepressor type)
  • The study of adenylate cyclase activity in orthostatic dysregulation
  • Usefulness of head-up tilt test in patients with suspected neurally mediate syncope after middle age
  • Relationship between mitochondrial ND1 gene mutation and pathological factors of renal cell carcinoma
  • Are Mitochondrial D-loop Mutations Useful as Prognostic Factors in Localized Renal Cell Carcinoma?
  • Relationship between adenylate cyclase activity and blood pressure in neurally mediated syncope patients using the head up tilt test
  • Changes in Adenylate Cyclase Activity in patients with Neurally Mediated Syncope
  • Changes in Adenylate Cyclase activity at rest in patients with Neurally Mediated Syncope
  • Clear cell renal cell carcinoma: evaluation of the pathological prognostic parameters recommended by the 2012 International Society of Urological Pathology Consensus Conference
  • Somatic Mutations in Mitochondrial DNA Predict Postoperative Recurrence in Renal Cell Carcinoma
  • Relationship between α2B-AR gene polymorphisms and differences in Adenylate Cyclase activity in Neurally Mediated Syncope
  • Correlation between mitochondrial ND1 gene mutation and recurrence after renal cell carcinoma
  • Clinicopathological study of renal cell carcinoma with rhabdoid differentiation
  • The Clinical Study for adenylate cyclase activity in Neurally Mediated Syncope
  • Correlation between mitochondrial DNA mutation and prognosis in patients with recurrent renal cell carcinoma

担当経験のある科目

  • Medical Informatics
  • Basics of pharmacology
  • Basics of genomic medicine
  • Medical informatics
  • Bioinformatics Literacy

所属学会

  • The Japanese Society of Child Neurology
  • The Japan Neuroscience Society
  • JAPAN SOCIETY OF NEUROVEGETATIVE RESEARCH
  • The Japanese Pharmacological Sciences
  • JAPANESE SOCIETY OF CLINICAL PHYSIOLOGY
  • The Molecular Biology Society of Japan
  • The Genetics Society of Japan
  • SOCIETY OF EVOLUTIONARY STUDIES, JAPAN
  • The Japanese Circulation Society

共同研究?競争的資金等の研究課題

Development of a novel kidney cancer drug targeting mitochondrial molecules

Diagnosis and therapeutic effect of neurally mediate syncope patients using adenylate cyclase activity fluctuation

The effect of the low ND1 expression in renal cancer cells on the intracellular ROS, tumor metastasis and proliferation

Candidate biomarkers for predicting drug response in cancer treatment

The role of dysautonomia and ADR in Takotsubo Cardiomyopathy

The acquisition methods for radiation-resistance by means of light irradiation.

Study on distribution and genomic diversity of new Asian pathogen amoeba

Basic research on therapeutic development targeting antitumor drug resistance factors

Origin of fighting spirit in polymorphism and evolution of dopamine receptor genes

The Role of Adrenaline in Neurally Mediated Syncope

ResearchMapへ移動します

Contact Us

Inquiries about coverage

Public Affairs Division Public Affairs and Communications Department

Tel. 0463-63-4670(direct dialing)