駒場 大峰

Komaba Hirotaka

  • 教授
  • 学位:博士(医学)

基本情報

所属

  • Undergraduate School of Medicine / Faculty of Medicine
  • Graduate School of Medicine / Course of Advanced Medical Science
  • Graduate School of Medicine / Course of Medical Science

ジャンル

  • Drugs

詳細情報

研究キーワード

  • Nephrology

研究分野

  • Life sciences Nephrology

受賞

  • AJKD Reviewer Hall of Fame

論文

Lower Parathyroid Hormone Levels are Associated With Reduced Fracture Risk in Japanese Patients on Hemodialysis.

Active vitamin D use and fractures in hemodialysis patients: Results from the international DOPPS.

Lower bone turnover and skeletal PTH responsiveness in Japanese compared to European patients on hemodialysis.

Parathyroidectomy vs cinacalcet among patients undergoing hemodialysis.

Secondary hyperparathyroidism, weight loss, and longer term mortality in haemodialysis patients: results from the DOPPS.

Fibroblast Growth Factor 23 and Mortality Among Prevalent Hemodialysis Patients in the Japan Dialysis Outcomes and Practice Patterns Study.

Metacarpal bone mineral density by radiographic absorptiometry predicts fracture risk in patients undergoing maintenance hemodialysis

Klotho expression in osteocytes regulates bone metabolism and controls bone formation

Phosphate-a poison for humans?

PTH/PTHrP receptor mediates cachexia in models of kidney failure and cancer

Parathyroidectomy and survival among Japanese hemodialysis patients with secondary hyperparathyroidism

The role of FGF23 in CKD—with or without Klotho

FGF23–parathyroid interaction: implications in chronic kidney disease

Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients

書籍等出版物

  • FGF23 and Klotho in Chronic Kidney Disease. Encyclopedia of Bone Biology.
  • Effect of PTH on the hematologic system. Parathyroid Glands in Chronic Kidney Disease.
  • Vitamin D and Klotho in chronic kidney disease. Vitamin D in Chronic Kidney Disease.
  • Role of FGF23 in CKD2-5. Mineral and Bone Disorders in Chronic Kidney Disease: Advances in pathogenesis, diagnosis and treatment.
  • Imaging and intervention of parathyroid hyperplasia. The Spectrum of Mineral and Bone Disorder in Chronic Kidney Disease (Oxford Clinical Nephrology Series)

講演?口頭発表等

  • The Great Wave of Japanese Evidence for CKD-MBD
  • A Look Forward: Clinical Implications of Translational Research in CKD-MBD
  • Bone-specific overexpression of membrane Klotho induces FGF23
  • Klotho in skeletal pathobiology
  • Phosphate binders and outcome.
  • Case for surgical parathyroidectomy.
  • New evidence and rationale for treatment of secondary hyperparathyroidism.
  • Medical and surgical management of secondary hyperparathyroidism: What can we learn from regional variation?
  • Effects of medical and surgical parathyroidectomy on bone fragility.

所属学会

  • International Society of Nephrology
  • American Society of Nephrology
  • Japanese Society for Bone and Mineral Research
  • Japanese Society for Dialysis Therapy
  • Japanese Society of Nephrology
  • Japanese Society of Internal Medicine
  • Japan Osteoporosis Society

共同研究?競争的資金等の研究課題

Role of proximal tubular Klotho in regulation of phosphate and vitamin D metabolism

Effect of PTH on energy and glucose metabolism in a mouse model of diabetes

The pathophysiological role of FGF23 in disordered mineral metabolism after acute kidney injury

Role of FGF23/Klotho system in pathophysiology of chronic kidney disease

Development of strategy for treatment of secondary hyperparathyroidism based on clinical and cost-effectiveness

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