飯島 崇利

Iijima Takatoshi

  • 准教授
  • 学位:博士(医学)

基本情報

所属

  • Undergraduate School of Medicine / Faculty of Medicine
  • Graduate School of Medicine / Course of Advanced Medical Science
  • Graduate School of Medicine / Course of Medical Science

詳細情報

研究キーワード

  • plasticity
  • transcriptome
  • Axon initial segment (AIS)
  • 3'UTR
  • mRNA
  • Autism spectrum disorder
  • synapse
  • RNA-binding protein
  • neuron
  • alternative splicing

研究分野

  • Life sciences Psychiatry
  • Life sciences Medical biochemistry
  • Life sciences Molecular biology
  • Life sciences Neuroscience - general

委員歴

  • Frontiers in Neuroplasticity and Development Review Editor
  • Frontiers in Molecular Neuroscience Review Editor

論文

The effects of corticotropin-releasing factor on motor learning.

Maternal immunoglobulin G affects brain development of mouse offspring.

Activity-regulated micro-exon splicing programs underlie late-onset plasticity at the axon initial segment

Neuronal SAM68 differentially regulates alternative last exon splicing and ensures proper synapse development and function

SAM68-regulated ALE selection of Pcdh15 maintains proper synapse development and function

Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP7 metabolism in enteric nervous system

Neuron-derived neurotrophic factor protects against dexamethasone-induced skeletal muscle atrophy.

Distinct Expression of SLM2 Underlies Splicing-Dependent Trans-Synaptic Signaling of Neurexin Across GABAergic Neuron Subtypes

SAM68-Specific Splicing Is Required for Proper Selection of Alternative 3′ UTR Isoforms in the Nervous System

A Perspective on the Role of Dynamic Alternative RNA Splicing in the Development, Specification, and Function of Axon Initial Segment.

Neuroligin-induced presynaptic differentiation through SLM2-mediated splicing modifications of neurexin in cerebellar cultures

Spatio-temporal and dynamic regulation of neurofascin alternative splicing in mouse cerebellar neurons

Spatio-temporal regulations and functions of neuronal alternative RNA splicing in developing and adult brains

Distinct Defects in Synaptic Differentiation of Neocortical Neurons in Response to Prenatal Valproate Exposure

Activity-Dependent Bidirectional Regulation of GAD Expression in a Homeostatic Fashion Is Mediated by BDNF-Dependent and Independent Pathways

Neuronal cell type-specific alternative splicing is regulated by the KH domain protein SLM1

Choreographing the Axo-Dendritic Dance

SAM68 Regulates Neuronal Activity-Dependent Alternative Splicing of Neurexin-1

Distinct expression of C1q-like family mRNAs in mouse brain and biochemical characterization of their encoded proteins

講演?口頭発表等

  • Axon initial segment in health and disorder
  • Alternative 3’UTR isoform selections by SAM68 insures proper synapse development and function

担当経験のある科目

  • Molecular and cellular medicine 2
  • Molecular and cellular medicine 1
  • Physiology I

所属学会

  • THE JAPANESE SOCIETY FOR NEUROCHEMISTRY
  • THE JAPAN NEUROSCIENCE SOCIETY
  • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

共同研究?競争的資金等の研究課題

Analysis of the effects of microglia on the developing brain

Establishment of specific inhibitory neuronal subtype differentiation and cell transplantation for the treatment of developmental disorders

Elicidation of molecular basis underlying the potential therapy and diagnosis on autism spectrum disorder by in vitro-based analyses

The RNA-based mechanism underlying pathophysiology in the neurological diseases

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